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butabarbital decreases effects of sufentanil SL by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Intently. Coadministration of CYP3A4 inducers may reduce sufentanil stages and efficacy, possibly precipitating withdrawal syndrome in sufferers which have produced Actual physical dependence to sufentanil. Discontinuatio

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